PDX Biospecimens
JAX is the premier provider of PDX frozen tumor fragments and FFPE slides for evaluating tumor structure and composition to best support your drug discovery research.
PDX & Mice Models
JAX offers a wide variety of PDX-Engrafted mice that can be purchased as a donor mouse with a tumor or in a cohort of newly passaged tumors intended for a study.
Preclinical Studies
Don't have access to a vivarium? JAX offers tailored efficacy testing studies for preclinical drug development, potentially saving you months of pre-study preparation time.
Our In Vivo Preclinical Services offer preclinical studies using PDX models. PDX-engrafted mice provide a fast and cost-effective platform to simulate trials, evaluate multiple drugs alone or in combination, and generate predictive data.
| Study Type Name | Description | PDX Model Options | Mouse Model Option | |
|---|---|---|---|---|
| PDX Live™ | Choose from a select list of readily available PDX tumors for engraftment on a mouse or let JAX conduct your study to get results for your therapeutic candidate | Select one of 15 available PDX Live™ models | See PDX Live™ Studies | |
| Onco-Hu™ Studies | Engraft your PDX of choice into a humanized mouse model to simulate the human immune system and tumor microenvironment | Choose from over 350 select PDX tumors | Humanized Mice such as | See Onco-Hu™ Studies |
| PDX Efficacy Studies | Choose any PDX tumor, cryopreserved or not, for engraftment. JAX study directors can help you choose which model, tumor, or study design best suits your research | Choose from over 350 select PDX tumors | Any NSG™ Portfolio Model | See PDX Efficacy Studies |
While JAX can facilitate your study using your preferred PDX and mouse models, it is not a requirement. If your team prefers to conduct the work independently, we offer several support options to assist you throughout your research process.
This webinar is designed as a practical guide for constructing the optimal preclinical cancer model for your research. We discuss selecting among xenografts, mouse models, and immune cell humanization approaches based on specific research questions and data requirements. If you're gearing up to evaluate your drug candidates in clinically-translatable, in vivo models, this webinar is for you.
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