Oncology Models And Study Capabilities
Be confident in your lead selection and dosing decisions with predictive and translationally relevant data delivered by JAX Preclinical Oncology Services.
PDX Library
- Confirm biomarkers with slides and FFPE samples
- RNASeq data available for many models
- Comprehensive efficacy studies available using your therapeutic
- Verified growth characteristics
- Low passage tumor models
Onco-Hu Studies
- Most translational model for immunotherapies
- Test therapeutic efficacy in the presence of human immune cells and human tumors
- Compare multiple CD34+ donors or multiple tumor profiles
HuPK For Antibody Therapeutics
- Accurately evaluates pharmacokinetics of monoclonal antibodies, bispecifics, ADCs, and albumin conjugates
- Determine first-in-human dosing
- Reduce dependency on non-human primates
CRS Safety Studies
- Test clinically-relevant cytokines in the presence or absence of tumor
- Compare multiple PBMC donors or multiple tumor models
- Measure downstream toxicities
- In-life measures and comprehensive histopathology available
