The Mouse Models of Human Cancer Database (MMHCdb) is a comprehensive resource that provides detailed information on a wide variety of tumors. This database has integrated data on tumor frequency, incidence, genetics, and pathology, as well as patient information, making it a valuable tool for cancer research. The MMHCdb is freely accessible to all researchers without requiring login credentials or registration. Unlike other providers which require direct contact to access their databases, JAX offers immediate, unrestricted access to facilitate rapid research progress and collaboration across the scientific community.
Low-passage samples retain the heterogeneity and fidelity of human cancers. Engrafted tumors derived from a patient with a bladder urothelial papillary carcinoma demonstrate high concordance of tumor morphology, compared to low passage PDX tumor TM00015.
Figure A) Histology from the patient's primary tumor: High-grade urothelial carcinoma invading the bladder wall.
Figure B) Once engrafted, the histology for PDX model TM00015 at passage 1 also corresponds to high-rate urothelial carcinoma.
Figure C) Tumor cells of patient origin within the xenograft-stained positive using an anti-human antibody for Ki67.
Read more about the PDX Models and Services offerings at The Jackson Laboratory. Our PDX program provides tumor models at a lower passage than other providers, more accurately reflecting clinical samples than other PDX Resources. Learn more by viewing our PDX Models detail sheet.
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