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Immune Humanized Mouse Models

CD34+ Humanized Mouse Model Comparison

Produced by engraftment of human cord blood derived hematopoietic stem cells (HSCs), these models yield stable multilineage immune cell development and enable long-term longitudinal studies. Customization and CD34+ HSC engraftment of other NSG and NRG variants are also available.

CD34+ Humanized Mouse Model Comparison

Strain NamesHuman Gene ExpressionBenefits

CD34+ Hu-NSG™
Stock Number: 705557
Naïve Strain Data Sheet

N/A
  • Multilineage engraftment
  • Foundational model for the NSG platform with thousands of publications
  • T cell-dependent inflammatory responses
  • No donor cell immune reactivity towards host

CD34+ Hu-NSG-SGM3
Stock Number: 701362
Naïve Strain Data Sheet

KITL (SCF), IL3, GM-CSF
  • Faster immune cell repopulation
  • Higher myeloid cell engraftment
  • Enhanced AML engraftment
  • High expression of mast cells

CD34+ Hu-NSG-IL15
Stock Number: 703089
Naïve Strain Data Sheet

IL15
  • Highest NK cell engraftment

CD34+ Hu-NSG-SGM3-IL15
Stock Number: 703321
Hu-NSG-SGM3-IL15 Data
Naïve Strain Data Sheet

KITL (SCF), IL3, GM-CSF, IL15
  • Reconstitution of T cell, Treg, myeloid cell, and mature natural killer cell populations
  • Enables evaluation of combinatorial therapeutics in concert with multiple cell lineages
  • Enables evaluation of combinatorial therapies evaluating T cells, NK cells, and myeloid cells

CD34+ Hu-NSG-FLT3
Stock Number: 703367
Hu-NSG-FLT3 Data
Naïve Strain Data Sheet

FLT3 Ligand
  • Enhanced reconstitution of T cells, Tregs, myeloid cells, and immature natural killer cells
  • Highest expression of conventional and plasmacytoid dendritic cells
  • More tumor infiltrating lymphocytes with CDX or PDX engraftments

CD34+ Hu-NSG-FLT3-IL15
Stock Number: 703722
Hu-NSG-FLT3-IL15 Data
Naïve Strain Data Sheet

FLT3 Ligand, IL15
  • Enhanced reconstitution of T cells, Tregs, myeloid cells, and mature natural killer cells
  • High expression of conventional and plasmacytoid dendritic cells
  • Diversity of immune cell models enables evaluation of combinatorial therapies that target T cells, NK cells, and relevant tumor micronenvironment cells.

PBMC Humanized Mouse Model Comparison

Created with adult peripheral blood mononuclear cells, the PBMC Hu-models feature quick engraftment and enable short-term efficacy and toxicity studies with mature human T cells.

Strain NamesHuman Gene ExpressionBenefits

PBMC Hu-NSG™
Stock Number: 745557
Naïve Strain Data Sheet

N/A
  • Enables short-term studies requiring effector and memory T cell function
  • Allows assessment of patient-specific and donor-to-donor immune responses to therapeutics

PBMC Hu-NSG™ MHC I/II DKO
Stock Number: 742516
Naïve Strain Data Sheet

N/A
  • Significantly delayed onset of GvHD
  • Allows assessment of patient-specific and donor-to-donor immune responses to therapeutics
  • Enables testing of cytokine release and downstream toxicity assays

Confidently Evaluate Your Therapies In The Humanized NSG Platform

Discover More

Why would drug developers test their antibody drug candidates in humanized mice?

Discover the indispensable role of humanized mice in biopharmaceutical research and their crucial importance in accurately modeling human diseases and immune responses. Immune cell humanized mice recapitulate critical components of the human immune system such as cells, cellular receptors, protein, cell-cell interactions, and individual diversity across a variety of donors. Through the engineering of a humanized immune system, researchers can rapidly advance the development of targeted treatments, providing valuable insights across various medical conditions.

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